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Cooperative nutrient scavenging is an evolutionary advantage in cancer
Gizem Guzelsoy*, Setiembre D. Elorza*, Manon Ros, Logan T. Schachtner, Makiko Hayashi, Spencer Hobson-Gutierrez, Parker Rundstrom, Julia S. Brunner, Ray Pillai, William E. Walkowicz, Lydia W. S. Finley, Maxime Deforet, Thales Papagiannakopoulos, Carlos Carmona-Fontaine
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Analysis code
Peer-reviewed publications
You can also find our publication list at NCBI Pubmed and Google Scholar.
Libi Anandi, Jeremy Garcia, Libuse Janska, Josephine Liu, Manon Ros, & Carmona-Fontaine C.
Direct visualization of emergent metastatic features within an ex vivo model of the tumor microenvironment. EMBO Life Science Alliance (2024). Vol 8(1)e202403053
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Schwörer S, Ros M, Tsanov, KM Cimino FV, Lowe SW, Carmona-Fontaine C & Thompson CB.
Hypoxia Potentiates the Inflammatory Fibroblast Phenotype Promoted by Pancreatic Cancer Cell–Derived Cytokines. Cancer Research (2023) 83 (10): 1596–1610. PDF.
Janská J, Anandi L, Kirchberger NC, Marinkovic ZS, Schachtner LT, Guzelsoy G & Carmona-Fontaine C The MEMIC is an ex vivo system to model the complexity of the tumor microenvironment. Disease Models & Mechanisms (2021) 14 (8): dmm048942.doi: ttps://doi.org/10.1242/dmm.048942 PDF
Cover Issue
Issue cover from Janská et al. (2021).
Morris IV JP, Yashinskie JJ, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marikovic Z, Sánchez-Rivera FJ, Leach SD, Carmona-Fontaine C, Thompson CB, Finley LWS & Lowe SW
α-Ketoglutarate links p53 to cell fate during tumour suppression.
Nature (2019) 573, 595–599
Modified from Morris et al. Nature (2019).
Vardhana SA, Arnold PK, Rosen BP, Chen Y, Carey BW, Huangfu D, Carmona-Fontaine C, Thompson CB & Finley LWS.
Glutamine independence is a selectable feature of pluripotent stem cells.
Nature Metabolism (2019)1, 676–687
Cover Issue
Issue cover for Vardhana et al. (2019).
Deforet M, Carmona-Fontaine C, Korolev KS & Xavier JB.
Evolution at the edge of expanding populations.
The American Naturalist (2019) Vol. 194, no. 3
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BioRxiv version.
Hobson-Gutierrez SA, Carmona-Fontaine C.
The metabolic axis of macrophage and immune cell polarization.
Disease Models & Mechanisms (2018) July11: dmm034462.
Invited Review for the Special Issue: Cancer metabolism: models, mechanisms and targets.
PMID: 29991530
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Carmona-Fontaine C*, Deforet D, Akkari L, Thompson CB*, Joyce JA, Xavier JB*.
Metabolic origins of spatial organization in the tumor microenvironment.
PNAS (2017) March;114(11):2934-9. doi: 10.1073/pnas.1700600114 PMID: 28246332
* Co-corresponding author.
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Intlekofer AM, Wang B, Liu H, Shah H, Carmona-Fontaine C, Rustenburg AS, Salah S, Gunner MR, Chodera JD, Cross JR, Thompson CB.
L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH.
Nature Chemical Biology. 2017. doi:10.1038/nchembio.2307 PMID: 28263965
Rabadán MA, Herrera A, Fanlo L, Usieto S, Carmona-Fontaine C, Mayor R, Pons S, Martí E.
Delamination of neural crest cells requires transient and reversible Wnt inhibition mediated by DACT1/2.
Development. 2016. doi: 10.1242/dev.134981 PMID: 27122165
Araya C, Carmona-Fontaine C, Clarke JD.
Extracellular matrix couples the convergence movements of mesoderm and neural plate during the early stages of neurulation.
Dev Dyn. 2016 May;245(5):580-9. doi: 10.1002/dvdy.24401. PMID: 26933766
Woods M, Carmona-Fontaine C, Barnes CP, Couzin ID, Mayor R, Page KM.
Directional Collective Cell Migration Emerges as a Property of Cell Interactions
PLoS One. 2014 DOI: 10.1371/journal.pone.0104969. PubMed PMID: 25181349.
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Araya C, Tawk M, Girdler GC, Costa M, Carmona-Fontaine C, Clarke JDW.
Mesoderm is required for coordinated cell movements within zebrafish neural plate in vivo.
Neural Development. 2014 9 (1), 9. PubMed PMID: 24755297.
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Deforet M, van Ditmarsch D, Carmona-Fontaine C and Xavier JB.
Hyperswarming adaptations in a bacterium improve collective motility without enhancing single cell motility
Soft Matter. 2014 14;10(14). PubMed PMID: 24622509.
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Carmona-Fontaine C*, Bucci V, Akkari L, Deforet M, Joyce JA, Xavier JB*.
Emergence of spatial structure in the tumor microenvironment due to the Warburg effect.
PNAS. 2013 Nov 26;110(48):19402-7. PubMed PMID: 24218566.
* Co-corresponding author.
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Chang WK, Carmona-Fontaine C, Xavier JB.
Tumour-stromal interactions generate emergent persistence in collective cancer cell migration.
Interface Focus. 2013 Aug 6;3(4):20130017. PubMed PMID: 24511381.
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Carmona-Fontaine C, Xavier JB.
Altruistic cell death and collective drug resistance.
Mol Syst Biol. 2012;8:627. PubMed PMID: 23169003.
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Carmona-Fontaine C, Theveneau E, Tzekou A, Tada M, Woods M, Page KM, Parsons M, Lambris JD, Mayor R.
Complement fragment C3a controls mutual cell attraction during collective cell migration.
Dev Cell. 2011 Dec 13;21(6):1026-37. PubMed PMID: 22118769.
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Mayor R, Carmona-Fontaine C.
Keeping in touch with contact inhibition of locomotion.
Trends Cell Biol. 2010 Jun;20(6):319-28. PubMed PMID: 20399659.
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Carmona-Fontaine C, Matthews H, Mayor R.
Directional cell migration in vivo: Wnt at the crest.
Cell Adh Migr. 2008 Oct-Dec;2(4):240-2. PubMed PMID: 19262160.
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Carmona-Fontaine C, Matthews HK, Kuriyama S, Moreno M, Dunn GA, Parsons M, Stern CD, Mayor R.
Contact inhibition of locomotion in vivo controls neural crest directional migration.
Nature. 2008 Dec 18;456(7224):957-61. PubMed PMID: 19078960.
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Matthews HK, Marchant L, Carmona-Fontaine C, Kuriyama S, Larraín J, Holt MR, Parsons M, Mayor R.
Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA.
Development. 2008 May;135(10):1771-80. PubMed PMID: 18403410.
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Carmona-Fontaine C, Acuña G, Ellwanger K, Niehrs C, Mayor R.
Neural crests are actively precluded from the anterior neural fold by a novel inhibitory mechanism dependent on Dickkopf1 secreted by the prechordal mesoderm.
Dev Biol. 2007 Sep 15;309(2):208-21. PubMed PMID: 17669393.
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Dagnino-Subiabre A, Orellana JA, Carmona-Fontaine C, Montiel J, Díaz-Velíz G, Serón-Ferré M, Wyneken U, Concha ML, Aboitiz F.
Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats.
J Neurochem. 2006 Jun;97(5):1279-87. PubMed PMID: 16539651.
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Rojas D, Carmona-Fontaine C, López-Calderón J, Aboitiz F.
Do discreteness and rivalry coexist in illusory motion reversals?
Vision Res. 2006 Mar;46(6-7):1155-7. PubMed PMID: 16139861.
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Dagnino-Subiabre A, Terreros G, Carmona-Fontaine C, Zepeda R, Orellana JA, Díaz-Véliz G, Mora S, Aboitiz F.
Chronic stress impairs acoustic conditioning more than visual conditioning in rats: morphological and behavioural evidence.
Neuroscience. 2005;135(4):1067-74. PubMed PMID: 16165300.
Steventon B, Carmona-Fontaine C, Mayor R.
Genetic network during neural crest induction: from cell specification to cell survival.
Semin Cell Dev Biol. 2005 Dec;16(6):647-54. PubMed PMID: 16084743.
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