Today our paper about how metabolites can act as morphogens that pattern the tumor microenvironment is out! You can access to it via the PNAS website and it is free to download.
Cancers appear as disordered mixtures of different cells, which is partly why they are hard to treat. We show here that despite this chaos, tumors show local organization that emerges from cellular processes common to most cancers: the altered metabolism of cancer cells and the interactions with stromal cells in the tumor microenvironment. With a multidisciplinary approach combining experiments and computer simulations we revealed that the metabolic activity of cancer cells produces gradients of nutrients and metabolic waste products that act as signals that cells use to know their position with respect to blood vessels. This positional information orchestrates a modular organization of tumor and stromal cells that resembles embryonic organization, which we could exploit as a therapeutic target.